Research
Independent computational research · 2026Connectomics & annotation QA
Connectome datasets like FlyWire and BANC come with annotations: cell types, predicted neurotransmitters, and other labels that people build analyses on top of. I wanted to know how stable those labels actually are, and what an honest answer looks like when the data runs out.
So I built comparisons I could rerun. Each one freezes its cohort, pins the exact release it reads from, and keeps an explicit "unknown" instead of quietly dropping cells that don't have a label. When two releases disagree, the workflow points at where. Every case study was checked again by an independent review before I counted it.
The findings are about the annotations and how reproducible they are. They say nothing about what a circuit does.
The findings are about annotation quality and reproducibility, not about what any circuit does.